| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761029 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Cellular senescence plays an important role in tumorigenesis and aging process. ⺠We demonstrated IGF-I enhanced cellular senescence in primary confluent cells. ⺠IGF-I enhanced cellular senescence in the ROS and p53-dependent manner. ⺠These results may explain the underlying mechanisms of IGF-I involvement in tumorigenesis and in regulation of aging.
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Authors
Anastasia-Evi Handayaningsih, Michiko Takahashi, Hidenori Fukuoka, Genzo Iguchi, Hitoshi Nishizawa, Masaaki Yamamoto, Kentaro Suda, Yutaka Takahashi,