JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-κB down regulation in MCF-7 breast cancer cells

► JNP3 inhibits cell invasion through the suppression of MMP-9 expression. ► JNP3 suppresses by blocking activation of NF-κB via ERK1/2 signaling pathways. ► JNP3 suppresses by blocking activation of JNK signaling. ► JNP3 represents potential anti-invasive and anti-metastatic agents as NF-κB inhibitor.