cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells

Article ID	Journal	Published Year	Pages	File Type
10761059	Biochemical and Biophysical Research Communications	2012	6 Pages	PDF

Abstract

âº cGK-I isoforms interact with a Rho effector, rhotekin. âº Rhotekin is phosphorylated by cGK-I at serine 93. âº cGK-I colocalizes with rhotekin in Neuro2A neuroblastoma cells. âº cGK-I suppresses RhoA-induced retraction via rhotekin in Neuro2A cells.

Keywords

GEF 8-pCPT-cGMP Rhotekin cGK VASP LPA cGMP all-trans-retinoic acid Neurite outgrowth Rho GAP guanine nucleotide exchange factor Vasodilator-stimulated phosphoprotein Nitric oxide GTPase-activating protein cGMP-dependent protein kinase Rho-associated kinase Rock

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells

Authors

Keizo Yuasa, Takeshi Nagame, Makoto Dohi, Yayoi Yanagita, Shin Yamagami, Masami Nagahama, Akihiko Tsuji,