| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761092 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Inflammation by Barrett's esophagus (BE) is a risk factor of its adenocarcinoma (BEA). ⺠8-Nitroguanine and 8-oxodG are inflammation-related DNA lesions. ⺠DNA lesions and iNOS expression were higher in the order, BEA > BE > normal tissues. ⺠Proton pump inhibitors suppress DNA damage by increasing Mn-SOD via Nrf2 activation. ⺠DNA lesions can be useful biomarkers to predict risk of BEA in BE patients.
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Authors
Raynoo Thanan, Ning Ma, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Tooru Shimosegawa, Somchai Pinlaor, Yusuke Hiraku, Shinji Oikawa, Mariko Murata, Shosuke Kawanishi,