Nuclear IL-33 is a transcriptional regulator of NF-ÎºB p65 and induces endothelial cell activation

Article ID	Journal	Published Year	Pages	File Type
10761108	Biochemical and Biophysical Research Communications	2012	7 Pages	PDF

Abstract

âº IL-33 as nuclear factor regulated expression of ICAM-1 and VCAM-1. âº Nuclear IL-33 increased the transcription of NF-ÎºB p65 by binding to the p65 promoter. âº Nuclear IL-33 controls NF-ÎºB-dependent inflammatory responses.

Keywords

CBM High-mobility group protein B1 VCAM-1 NF-κB p65 HMGB1 qRT-PCR ICAM-1 HUVECS NF-κB HEV Small interfering RNA siRNA inflammation chromatin immunoprecipitation interleukin Interleukin-33 quantitative reverse transcription-PCR Human umbilical vein endothelial cells nuclear factor-κB cell adhesion molecules intercellular adhesion molecule-1 vascular cell adhesion molecule high endothelial venule high endothelial venules CHiP