The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice

Article ID	Journal	Published Year	Pages	File Type
10761114	Biochemical and Biophysical Research Communications	2012	5 Pages	PDF

Abstract

âº Nerve injury induced the activation of ceramide biosynthesis in the spinal cord. âº Ceramide biosynthesis inhibitor prevented allodynia and microglial activation. âº Spinal ceramide may be a novel critical molecule for neuropathic pain.

Keywords

CerS PBS PSL SMase FB1 SCN IL-1β DMSO Allodynia i.t.sphingolipids sphingomyelinase intrathecal Interleukin-1β tumor necrosis factor-α Dimethyl sulfoxide ceramide synthase Cytokines dorsal horn Sciatic nerve TNF-α Phosphate buffered saline Fumonisin B1 Microglia Partial sciatic nerve ligation