| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761142 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Pancreatic stellate cells (PSCs) promote the progression of pancreatic cancer. ⺠Pancreatic cancer cells co-cultured with PSCs showed enhanced spheroid formation. ⺠Expression of stem cell-related genes ABCG2, Nestin and LIN28 was increased. ⺠Co-injection of PSCs enhanced tumorigenicity of pancreatic cancer cells in vivo. ⺠This study suggested a novel role of PSCs as a part of the cancer stem cell niche.
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Authors
Shin Hamada, Atsushi Masamune, Tetsuya Takikawa, Noriaki Suzuki, Kazuhiro Kikuta, Morihisa Hirota, Hirofumi Hamada, Masayoshi Kobune, Kennichi Satoh, Tooru Shimosegawa,