| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761169 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠HIC1 interacts with SIRT1 through its BTB/POZ and 4 Zinc fingers domains. ⺠SIRT1 interacts with HIC1 through its catalytic and C-terminal ESA domains. ⺠The ESA domain contains two Serine residues phosphorylated by CKII upon DNA-damages. ⺠TBCA, an inhibitor of CKII, inhibits the interaction between HIC1 and SIRT1. ⺠The acetylation/SUMOylation switch of HIC1 regulates the DNA damage response.
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Authors
Vanessa Dehennaut, Ingrid Loison, Sébastien Pinte, Dominique Leprince,