Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancer cell growth in vitro and in vivo

Article ID	Journal	Published Year	Pages	File Type
10761172	Biochemical and Biophysical Research Communications	2012	7 Pages	PDF

Abstract

âº Hsp90 is over-expressed in human breast cancer. âº The shRNA-mediated gene silencing of Hsp90 resulted in inhibition of cell growth. âº Akt and NF-kB were down-regulation after transfection due to Hsp90 silencing. âº The tumor growth ratio was decline due to Hsp90 silencing. âº The PCNA expression was down-regulation due to Hsp90 silencing.

Keywords

short hairpin RNA Breast cancer MCF-7 cell Heat shock protein 90

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancer cell growth in vitro and in vivo

Authors

Keqiang Zuo, Dan Li, Benjamin Pulli, Fei Yu, Haidong Cai, Xueyu Yuan, Xiaoping Zhang, Zhongwei Lv,