| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761190 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠ACh and ET-1 activate a K+ current in cardiac atrioventricular nodal cells. ⺠Tertiapin-Q sensitive IKACh activated via M2 receptors shows bi-exponential 'fade'. ⺠ET-1 activates a similar current that also fades. ⺠The fade reflects desensitization rather than altered K+ ion driving force. ⺠Acetylcholine is able to cross-desensitize the AVN cell response to endothelin-1.
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Authors
Stéphanie C.M. Choisy, Andrew F. James, Jules C. Hancox,