Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10761192 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠miR-191 expression is upregulated in senescencent human epidermal keratinocytes. ⺠miR-191 overexpression is sufficient per se to induce senescence in keratinocytes. ⺠SATB1 and CDK6 are downregulated in senescence and are direct miR-191 targets. ⺠SATB1 and CDK6 silencing by siRNA triggers senescence in HEKn cells.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
A.M. Lena, M. Mancini, P. Rivetti di Val Cervo, G. Saintigny, C. Mahé, G. Melino, E. Candi,