| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761192 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠miR-191 expression is upregulated in senescencent human epidermal keratinocytes. ⺠miR-191 overexpression is sufficient per se to induce senescence in keratinocytes. ⺠SATB1 and CDK6 are downregulated in senescence and are direct miR-191 targets. ⺠SATB1 and CDK6 silencing by siRNA triggers senescence in HEKn cells.
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Authors
A.M. Lena, M. Mancini, P. Rivetti di Val Cervo, G. Saintigny, C. Mahé, G. Melino, E. Candi,