| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761205 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠We found significant Keap1 promoter demethylation in diabetic cataractous lenses. ⺠Demethylation of Keap1 gene upregulated the expression of Keap1 mRNA and protein. ⺠Elevated levels of Keap1 are known to decrease the levels of Nrf2. ⺠Thereby, the levels of antioxidant enzymes are suppressed by decreased Nrf2 level.
Keywords
FCSHLECsKelch-like ECH associated protein 1DNA demethylationage-related cataractsARCsUPRBGSNrf2PBS2′,7′-dichlorodihydrofluorescein diacetate5-Azakeap1ROSCpG islandsfetal calf serumhuman lens epithelial cellsendoplasmic reticulumNF-E2-related factor 2antioxidant response elementPhosphate buffered salineAREUnfolded protein responseReactive oxygen species
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Authors
Periyasamy Palsamy, Masahiko Ayaki, Rajan Elanchezhian, Toshimichi Shinohara,