| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761208 | Biochemical and Biophysical Research Communications | 2012 | 4 Pages |
Abstract
⺠D2HGDH is a causative gene of D-2-hydroxyglutaric aciduria type I. ⺠Knockdown of D2HGDH increased 2-hydroxyglutarate in cells. ⺠Knockdown of IDH1 and IDH2 decreased 2-hydroxyglutarate in D2HGDH depleted cells. ⺠Expression of IDH1 or IDH2 increased 2-hydroxyglutarate in cells.
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Authors
Hironori Matsunaga, Akiko Futakuchi-Tsuchida, Makoto Takahashi, Tomio Ishikawa, Makoto Tsuji, Osamu Ando,