Article ID Journal Published Year Pages File Type
10761225 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► Dn-PKC-ε and dn-PKC-δ showed distinct subcellular localization in adult myocytes. ► ET-1 induces positive inotropy, increase in [Ca2+]i and increase in Ca sensitivity. ► The effects of ET-1 were abolished by dn-PKC-ε overexpression but not by dn-PKC-δ. ► The data suggest that PKCε has a critical role in ET-1-induced changes.
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