| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761261 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠SENP1 knockout chicken DT40 cells are hypersensitive to spindle poisons. ⺠Spindle poison treatment of SENP1â/â cells leads to increased mitotic slippage. ⺠Mitotic slippage in SENP1â/â cells associates with apoptosis and endoreplication. ⺠SENP1 counteracts sister chromatid separation during mitotic arrest. ⺠Plk1-mediated cohesion down-regulation is involved in colcemid cytotoxicity.
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Authors
Saho Era, Takuya Abe, Hiroshi Arakawa, Shunsuke Kobayashi, Barnabas Szakal, Yusuke Yoshikawa, Akira Motegi, Shunichi Takeda, Dana Branzei,