Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis

Article ID	Journal	Published Year	Pages	File Type
10761276	Biochemical and Biophysical Research Communications	2012	8 Pages	PDF

Abstract

âº We examined the expression and role of TLR9 in Helicobacter pylori-induced gastritis. âº TLR9 was expressed in the macrophages, dendritic cells, and CD3+ cells. âº TNF-Î± and IFN-Î³ levels in TLR9 KO mice were higher than those in wild-type mice. âº Administration of IFN-Î± decreased TNF-Î± and IFN-Î³ levels in TLR9 KO mice. âº TLR9 has IFN-Î±-mediated anti-inflammatory properties in H. pylori-induced gastritis.

Keywords

TRAF PECAM IRF DCs T helper NEMO BCA CFUs RT-PCR platelet/endothelial cell adhesion molecule TNF NF-κB PBS TRAF family member-associated NF-κB activator CpG-ODN CpG-oligodeoxynucleotide MYD88 DSS MPO MAPK TLRs interferon IFN Interferon-α Interferon-β interferon-γ interleukin bicinchoninic acid tumor necrosis factor-α standard error of mean Dendritic cells Dextran sulfate sodium myeloid differentiation factor 88 interferon regulatory factor TNF receptor-associated factor tumor necrosis factor nuclear factor-κB Phosphate-buffered saline tank SEM NF-κB essential modulator myeloperoxidase knockout colony-forming units Reverse transcriptase-polymerase chain reaction mitogen-activated protein kinase Toll-like receptors