Article ID Journal Published Year Pages File Type
10761280 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► PanZ is required for formation of the pyruvoyl-cofactor in PanD (ADC) in vivo. ► PanZ and PanD interact with nanomolar affinity. ► Interaction of PanZ and PanD is dependent upon coenzyme A. ► PanZ and PanD form a heterooctameric complex which binds four molecules of CoA.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Formation of a heterooctameric complex between aspartate α-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent
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