Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10761381 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠miR-21 directly targets and represses JAG1 levels in breast cancer cells. ⺠miR-21 targeting of JAG1 is affected by miR-21 levels. ⺠miR-21 and JAG1 expression levels are negatively correlated. ⺠17beta-estradiol (E2) reduces mir-21 levels thereby increasing JAG1 levels. ⺠A novel regulatory interplay between miR-21, JAG1 and E2 in breast cancer cells.
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Authors
S. Duygu Selcuklu, Mark T.A. Donoghue, Michael J. Kerin, Charles Spillane,