Article ID Journal Published Year Pages File Type
10761381 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► miR-21 directly targets and represses JAG1 levels in breast cancer cells. ► miR-21 targeting of JAG1 is affected by miR-21 levels. ► miR-21 and JAG1 expression levels are negatively correlated. ► 17beta-estradiol (E2) reduces mir-21 levels thereby increasing JAG1 levels. ► A novel regulatory interplay between miR-21, JAG1 and E2 in breast cancer cells.
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