| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761389 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠SIRT1 inhibits protein levels of β-catenin and its transcriptional activity. ⺠Nuclear localization of SIRT1 is not required for the decrease of β-catenin expression. ⺠SIRT1-mediated degradation of β-catenin is not required for GSK-3β and Siah-1 but for proteosome. ⺠SIRT1 activation inhibits proliferation of pancreatic cancer cells expressing PAUF.
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Authors
Il-Rae Cho, Sang Seok Koh, Waraporn Malilas, Ratakorn Srisuttee, Jeong Moon, Young-Whan Choi, Yoshiyuki Horio, Sangtaek Oh, Young-Hwa Chung,