| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761390 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Eighty percentage of poly(ADP-ribose) polymerase activity is inhibited by oral administration of GPI 15427. ⺠Both pre- and post-injury GPI 15427 treatments have neuroprotective effects. ⺠GPI 15427 suppresses ischemia and reperfusion-induced PERK-eIF2α-CHOP activation and Bip over-expression.
Keywords
PDIGFAPOPLPARPGCLATF6ONLIPLINLeIF2αBiPI/RIRE1αER stressischemia and reperfusionCHOPendoplasmic reticulumactivating transcription factor 6outer plexiform layerouter nuclear layerinner plexiform layerinner nuclear layerganglion cell layerNeuroprotectionGlial fibrillary acidic proteinprotein disulfide isomerasePERKPoly(ADP-ribose) polymerase
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Authors
Chuanzhou Li, Leilei Wang, Timothy S. Kern, Ling Zheng,