Glycogen synthase kinase 3-Î² phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization

Article ID	Journal	Published Year	Pages	File Type
10761392	Biochemical and Biophysical Research Communications	2012	7 Pages	PDF

Abstract

âº Novel S/T-P-S/T domains were identified in NICD. âº Phosphorylation of NICD on the S/T-P-S/T domains induced nuclear localization. âº GSK-3Î² phosphorylated S and T residues in NICD S/T-P-S/T domains.

Keywords

GSK-3β NLS Notch

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Glycogen synthase kinase 3-Î² phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization

Authors

Xiangzi Han, Ji-hyun Ju, Incheol Shin,