| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761404 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠Lysosomal glucosylceramidase (beta-glucosidase 1, GBA1) is in addition to the non-lysosomal glucosylceramidase (beta-glucosidase 2, GBA2) a second bile acid beta-glucosidase. ⺠Using bile acid β-glucosides as substrate, GBA1 and GBA2 can be determined in different tissues. ⺠GBA2 activity is in brain tissue higher as compared to GBA1 activity. ⺠Living primary fibroblasts metabolise exogenous bile acid β-glucosides.
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Authors
Klaus Harzer, Yotam Blech-Hermoni, Ehud Goldin, Ursula Felderhoff-Mueser, Claudia Igney, Ellen Sidransky, Yildiz Yildiz,