| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761407 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠The study revealed the detailed resistance mechanism of the non-active mutation C1156Y in ALK. ⺠C1156Y leads to crizotinib displacement and conformational changes in the binding cavity. ⺠The conformations cause a decline in the vdW and electrostatic energy between crizotinib and ALK.
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Authors
Hui-Yong Sun, Feng-Qin Ji,