| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761438 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠We dissect how individual disulfide bond affects the amyloidogenicity of insulin. ⺠A controlled reduction system for insulin is established in this study. ⺠Disulfide breakage is associated with unfolding and increased amyloidogenicity. ⺠Breakage of A6-A11 is associated with significantly increased cytotoxicity. ⺠Analogs without A6-A11 have a higher potency to form high order toxic oligomers.
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Authors
Yang Li, Hao Gong, Yue Sun, Juan Yan, Biao Cheng, Xin Zhang, Jing Huang, Mengying Yu, Yu Guo, Ling Zheng, Kun Huang,