Article ID Journal Published Year Pages File Type
10761499 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► Low dose lidamycin induced neural differentiation in mouse P19 EC cells. ► A mechanism of lidamycin induced differentiation is through down-regulation of Oct4. ► Down-regulation of Oct4 by lidamycin caused activation of p21 gene expression. ► Lidamycin has its anti-cancer effect on inducing cell differentiation in P19 cells.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Lidamycin induces neural differentiation of mouse embryonic carcinoma cells through down-regulation of transcription factor Oct4
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