| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761522 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠We established GEM-resistant cell lines from 6 human cancer cell lines. ⺠There were no abnormalities on influx and efflux of GEM. ⺠Inactivating mutations of deoxycytidine kinase (DCK) were found in 5 of 6 GEM-resistant cell lines. ⺠Introduction of DCK into restored GEM sensitivities and knockdown yielded GEM resistance. ⺠Inactivation of DCK plays a crucial role for acquisition of GEM resistance.
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Authors
Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba, Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh Kashkouli Nezhad, Guo Jin, Shinichi Fukushige,