| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761535 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Hsp90 inhibition destabilized PDK1 in Huh7 cells through the proteosome pathway. ⺠Destabilization of PDK1 led to decrease in the abundance of active form PRK2 level. ⺠Hsp90 inhibitor 17-DMAG abrogated PRK2-mediated HCV NS5B phosphorylation. ⺠Combination of 17-DMAG and a PRK2 inhibitor effectively suppressed HCV replication.
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Authors
Mi-Gyeong Kim, Jae-Su Moon, Eun-Jung Kim, Seung-Hoon Lee, Jong-Won Oh,