CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC

Article ID	Journal	Published Year	Pages	File Type
10761608	Biochemical and Biophysical Research Communications	2012	7 Pages	PDF

Abstract

âº RBL, a potent mitogenic and complex N-glycan specific lectin binds to CD45 on PBMC. âº RBL triggers CD45-mediated signaling involved in activation of p38MAPK and STAT-5. âº Inhibition of CD45 PTPase signaling blocks RBL-induced ZAP70 phosphorylation. âº RBL-CD45 mediated signaling is crucial for RBL-induced immunodulatory activities.

Keywords

PBMC CD45 RBL ZAP-70 STAT-5 IL-2Rα MAPK STAT Proliferation peripheral blood mononuclear cells Cytokines signal transducers and activators of transcription mitogen activated protein kinase Interleukin-2 receptor alpha

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Preview

CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC

Authors

Radha Pujari, Sachin M. Eligar, Natesh Kumar, Nagaraja N. Nagre, Shashikala R. Inamdar, Bale M. Swamy, Padma Shastry,