| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761614 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠Two T cell lines stimulate PTHrP, RANKL, MMP13 gene expression in GCT cell cultures. ⺠CD40 expressed by stromal cells; CD40L detected in whole tumor but not cultures. ⺠Effect of CD40L treatment on GCT cells increased PTHrP and MMP13 gene expression. ⺠PTHrP treatment increased MMP13 expression, while inhibition decreased expression. ⺠T cells may stimulate GCT stromal cells and promote the osteolysis of the tumor.
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Authors
Robert W. Cowan, Michelle Ghert, Gurmit Singh,