Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger

Article ID	Journal	Published Year	Pages	File Type
10761623	Biochemical and Biophysical Research Communications	2012	6 Pages	PDF

Abstract

âº 1-Dehydro-10-gingerdione (1D10G) from ginger inhibits LPS binding to MD-2. âº 1D10G suppresses MyD88- or TRIF-dependent signaling in LPS-activated macrophages. âº 1D10G down-regulates the expression of NF-ÎºB-, AP1- or IRF3-target genes. âº MD-2 is a molecular target in the anti-inflammatory action of 1D10G.

Keywords

IκB IP-10 AP1 IRF3 TLR4 MD-2 iNOS LBP COX-2 MYD88 IFN regulatory factor 3 LPS NF-κB TRIF interferon IFN interleukin Bis-ANS tumor necrosis factor α inducible nitric oxide synthase cyclooxygenase 2 myeloid differentiation factor 88 TNF-α nuclear factor-κB activating protein 1 lipopolysaccharide inhibitory κB LPS-binding protein myeloid differentiation protein 2 Toll-like receptor 4