Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10761623 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠1-Dehydro-10-gingerdione (1D10G) from ginger inhibits LPS binding to MD-2. ⺠1D10G suppresses MyD88- or TRIF-dependent signaling in LPS-activated macrophages. ⺠1D10G down-regulates the expression of NF-κB-, AP1- or IRF3-target genes. ⺠MD-2 is a molecular target in the anti-inflammatory action of 1D10G.
Keywords
IκBIP-10AP1IRF3TLR4MD-2iNOSLBPCOX-2MYD88IFN regulatory factor 3LPSNF-κBTRIFinterferonIFNinterleukinBis-ANStumor necrosis factor αinducible nitric oxide synthasecyclooxygenase 2myeloid differentiation factor 88TNF-αnuclear factor-κBactivating protein 1lipopolysaccharideinhibitory κBLPS-binding proteinmyeloid differentiation protein 2Toll-like receptor 4
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Authors
Sun Hong Park, Min Sik Kyeong, Yuri Hwang, Shi Yong Ryu, Sang-Bae Han, Youngsoo Kim,