Article ID Journal Published Year Pages File Type
10761669 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► Endothelial dysfunction is an early indicator of vascular damage. ► Effects of diabetic glucolipotoxicity were studied in human coronary endothelial cells. ► Genes involved in angiogenesis, inflammation and thrombogenesis were changed. ► These aberrations were normalized by GLP-1 receptor agonist exendin-4. ► Exendin-4 may confer cardiovascular benefit beyond improved glycemic control.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Exendin-4 restores glucolipotoxicity-induced gene expression in human coronary artery endothelial cells
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