| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761760 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠In human TH2 cells, IL4 and IL13 genes are regulated in a coordinated manner. ⺠IL4 and IL13 are both regulated by the transcription factors NFAT1 and TBET. ⺠Upon cell stimulation, NFAT1 translocates into the nucleus. ⺠In the nucleus NFAT1 associates with GATA3 at the promoter regions of IL4 and IL13. ⺠3C analysis showed looping of IL4 and 13 to form a structure poised for transcription.
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Authors
Xin Yao, Wangjian Zha, Wei Song, Haiyan He, Mao Huang, Elen Jazrawi, Paul Lavender, Peter J. Barnes, Ian M. Adcock, Andrew L. Durham,