| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761765 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠We established Trypanosoma cruzi lacking the gene for carbamoyl phosphate synthetase II. ⺠Disruption of the cpsII gene significantly reduced the growth of epimastigotes. ⺠In particular, the CPSII-null mutant severely retarded intracellular growth. ⺠The de novo pyrimidine pathway is critical for the parasite growth in the host cell.
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Authors
Muneaki Hashimoto, Jorge Morales, Yoshihisa Fukai, Shigeo Suzuki, Shinzaburo Takamiya, Akiko Tsubouchi, Syou Inoue, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada, Akiko Tanaka, Takashi Aoki, Takeshi Nara,