| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761782 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠We examined OXPHOS and citrate synthase enzyme activities in HEK293 cells devoid of mtDNA. ⺠Enzymes partially encoded by mtDNA show reduced activities. ⺠Also the entirely nuclear encoded complex II and citrate synthase exhibit reduced activities. ⺠Loss of mtDNA induces a feedback mechanism that downregulates complex II and citrate synthase.
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Authors
Edith E. Mueller, Johannes A. Mayr, Franz A. Zimmermann, René G. Feichtinger, Olaf Stanger, Wolfgang Sperl, Barbara Kofler,