| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761786 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠LKB1 expression is lower in ERα-positive MCF-7 than ERα-negative breast cancer cells. ⺠ERα knock-down in MCF-7s increases LKB1 promoter activity/expression. ⺠Putative estrogen response elements are present throughout the LKB1 promoter region. ⺠E2 up-regulates LKB1 transcription/mRNA levels, decreasing ERα expression. ⺠Actinomycin D transcriptionally blocks the E2-mediated increase in LKB1 mRNA levels.
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Authors
Katja Linher-Melville, Stephanie Zantinge, Gurmit Singh,