| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761793 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Oncogenic RAS upregulates EZH2 and downregulates RUNX3 in pancreatic cancer. ⺠We used the transgenic rat exogenously expressing human mutant RAS. ⺠Ezh2 protein upregulation is an initiating event in rat pancreatic carcinogenesis. ⺠MEK-inhibition or Elk-1-knockdown downregulates EZH2 and restores RUNX3. ⺠Elk-1- or EZH2-knockdown inhibits growth of pancreatic cancer cells.
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Authors
Satoshi Fujii, Katsumi Fukamachi, Hiroyuki Tsuda, Kosei Ito, Yoshiaki Ito, Atsushi Ochiai,