| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761799 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Two cell-based reporter platforms were established for screening of EBNA1 inhibitors. ⺠EGCG acts as an inhibitor to block EBNA1 binding with the cognate oriP sequence. ⺠EGCG debilitates EBNA1-dependent transcription enhancement and episome maintenance. ⺠EGCG impairs persistence of EBV latency. ⺠EGCG is a potent anti-EBV agent for targeting the latent cascade of EBV.
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Authors
Ya-Lin Chen, Hsing-Lyn Tsai, Chih-Wen Peng,