Article ID Journal Published Year Pages File Type
10761847 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► PUMA/NOXA BH3s both interact with p53 DBD in vitro. ► 3D structure predicted the p53-PUMA/NOXA interaction. ► T102A, L111A, D186A and G199A disrupted the p53-PUMA/NOXA interaction. ► Four mutations structurally destabilized p53 and induced the aggregation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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In vitro binding properties of tumor suppressor p53 with PUMA and NOXA
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