| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761864 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠RCAN1 physically interacts with STAT2 in mammalian cells, resulting in decreased RCAN1 protein levels. ⺠STAT2 reduces RCAN1 levels through the ubiquitin E3 ligase FBW7. ⺠IFN-α-activated STAT2 enhances the RCAN1 degradation. ⺠This study provides an evidence of a cytokine-induced RCAN1 degradation pathway involving STAT2 and FBW7.
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Authors
Jee Won Lee, Hye Seon Kang, Jae Youn Lee, Eun Jung Lee, Hyewhon Rhim, Joo Heon Yoon, Su Ryeon Seo, Kwang Chul Chung,