| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761900 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠We investigated physiological significance of hydroxylation of sphingolipid in yeast. ⺠Defect of sphingolipid hydroxylase gene alters sensitivity of cells to AUR1 repression. ⺠Two hydroxylase genes, SUR2 and SCS7, have different effect to the sensitivity. ⺠It is suggested that the hydroxylation states of ceramide determine its toxicity.
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Authors
Motohiro Tani, Osamu Kuge,