Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10761925 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠We examine whether ER Ca2+-binding protein calumin modulates CRAC channel activity. ⺠Co-expression of calumin with Orai1 does not form CRAC channel. ⺠Calumin is directly associated with Orai1 and STIM1. ⺠Ca2+ permeability of CRAC channels is decreased when co-expressed with calumin. ⺠Ca2+ influx via CRAC channels is attenuated by co-transfection of calumin.
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Authors
Masakazu Konno, Hisashi Shirakawa, Takahito Miyake, Shinya Sakimoto, Takayuki Nakagawa, Shuji Kaneko,