Article ID Journal Published Year Pages File Type
10761929 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► IVIG induces emission of reactive oxygen species (ROS) from TNF-α-primed neutrophils. ► Monomeric IgG in IVIG can induce ROS emissions from TNF-α-primed neutrophils. ► Both Fab and Fc domains of IVIG are essential for the ROS emission of neutrophils. ► IVIG binding to antigen(s) and FcγIIIB receptors on neutrophils induces ROS emission.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Both the Fab and Fc domains of IgG are essential for ROS emission from TNF-α-primed neutrophils by IVIG
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