| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761939 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Mechanical stimulation is an important factor for regulation of stem cell fate. ⺠Cyclic stretch to human induced pluripotent stem cells activated small GTPase Rho. ⺠Rho-kinase activation attenuated pluripotency via inhibition of AKT activation. ⺠This reaction could be reproduced only by transfection of dominant active Rho. ⺠Rho/ROCK are important molecules in mechanotransduction and control of stemness.
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Authors
Takeshi Teramura, Toshiyuki Takehara, Yuta Onodera, Koichi Nakagawa, Chiaki Hamanishi, Kanji Fukuda,