Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10761939 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Mechanical stimulation is an important factor for regulation of stem cell fate. ⺠Cyclic stretch to human induced pluripotent stem cells activated small GTPase Rho. ⺠Rho-kinase activation attenuated pluripotency via inhibition of AKT activation. ⺠This reaction could be reproduced only by transfection of dominant active Rho. ⺠Rho/ROCK are important molecules in mechanotransduction and control of stemness.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Takeshi Teramura, Toshiyuki Takehara, Yuta Onodera, Koichi Nakagawa, Chiaki Hamanishi, Kanji Fukuda,