Article ID Journal Published Year Pages File Type
10761948 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► We recently discovered a potent and selective B-Raf inhibitor, UI-152. ► UI-152 displayed a selective cytotoxicity toward v-Ha-ras transformed cells. ► UI-152-induced growth inhibition was largely meditated by autophagy. ► UI-152 induced paradoxical activation of Raf-1.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts
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