| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761986 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠We generated a system to study gene function in normal megakaryocytopoiesis. ⺠ES cells with transgenes differentiate into megakaryocytes and proplatelets. ⺠Transgene expression in the Hprt locus is suppressed in megakaryocytic cells. ⺠β-Globin insulators drastically improve transgene expression. ⺠Transgene is activated specifically in megakaryocytic cells.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yoshiaki Okada, Masaaki Yonekura, Miho Watanabe, Tomoko Nakai, Atsuko Wakimura, Mikiko Shimizu, Yuko Kamikawa, Mie Kitayama, Kenji Kitajima, William C. Aird, Takefumi Doi,