| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762003 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠HAb18G/CD147 forms dimers both in solution and in living cells. ⺠Dimerization of HAb18G/CD147 can be disrupted by mutagenesis. ⺠Key residues for dimerization of HAb18G/CD147 were identified. ⺠Disruption of HAb18G/CD147 dimerization attenuates the MAPK activation in tumor. ⺠Dimerization is required for HAb18G/CD147 induced MMP2 expression and tumor invasion.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Hong-Yong Cui, Tao Guo, Shi-Jie Wang, Pu Zhao, Zhi-Shou Dong, Yang Zhang, Jian-Li Jiang, Zhi-Nan Chen, Xiao-Ling Yu,