| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762015 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠The protein POT1 plays an important role in telomere protection. ⺠Functional POT1 was overexpressed in Escherichia coli for the first time, and purified. ⺠Compound Sysu-00692 was found to be the first POT1-binding ligand. ⺠Sysu-00692 could interfere with the binding activity of POT1 in vivo. ⺠Sysu-00692 had inhibition on telomerase and cell proliferation.
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Authors
Nannan Xiao, Siqi Chen, Yan Ma, Jun Qiu, Jia-Heng Tan, Tian-Miao Ou, Lian-Quan Gu, Zhi-Shu Huang, Ding Li,