| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762024 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠C3 is activated during biliary obstruction in both WT and C5-deficient mice. ⺠C5 significantly attenuates the amount of fibrosis in response upon BDL. ⺠C5-deficient mice show decreased expression of fibrosis-associated genes and TNF-α. ⺠Reduced peribiliary infiltration of leucocytes in fibrotic areas with C5 deficiency. ⺠Decreased expression of MMP-9 and decreased gelatinase activity in C5-deficient mice.
Keywords
TGFTNFNtcpFXRPBCMMP9α-SMAMRPBDLPSCMMPfarnesoid X receptorAlpha-smooth muscle actinBile acidCholestatic liver diseasetransforming growth factorPrimary biliary cirrhosistumor necrosis factorLeukocytesmatrix metalloproteinasemultidrug resistance associated proteinbile duct ligationPrimary sclerosing cholangitisCollagencol
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Authors
Johannes Schmitt, Martin Roderfeld, Karim Sabrane, Pan Zhang, Yinghua Tian, Joachim C. Mertens, Pascal Frei, Bruno Stieger, Achim Weber, Beat Müllhaupt, Elke Roeb, Andreas Geier,