| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762027 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠Cytochrome P450BM-3 reduced aldehydes to alcohols efficiently (kcat â¼Â 25 minâ1). ⺠Reduction is a direct hydride transfer from R-NADP2H to the carbonyl moiety. ⺠P450 domain variants enhance reduction through potential allosteric/redox interactions. ⺠Novel reaction will have implications for metabolism of xenobiotics.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Rüdiger Kaspera, Tariku Sahele, Kyle Lakatos, Rheem A. Totah,