| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762035 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠We found that keratinocyte-derived Angptl2 plays roles in the pathogenesis of DM. ⺠Keratinocyte-specific Angptl2 Tg mice showed skin phenotypes similar to DM patients. ⺠Angptl2 activates the NF-κB inflammatory cascade in keratinocytes. ⺠Angptl2 increased expression of proinflammatory cytokines, IL-1β and IL-6.
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Authors
Aki Ogata, Motoyoshi Endo, Jun Aoi, Otowa Takahashi, Tsuyoshi Kadomatsu, Keishi Miyata, Zhe Tian, Masatoshi Jinnin, Satoshi Fukushima, Hironobu Ihn, Yuichi Oike,